You should delete your Cyberpunk 2077 mods ahead of update 2.0, and you may need to do a clean reinstall of the game

pcgamer.com:

I figured I was going to have to uninstall my Cyberpunk 2077 mods before checking out Phantom Liberty and update 2.0⁠. Most of the mods I went for on my last playthrough were difficulty and loot adjustments that'd clash with 2.0's big changes, and for the rest, mod authors would likely need to update their files to play nice with the patch. What I wasn't expecting was needing to do a clean reinstall⁠—complete with deleting some leftover files⁠—to clear up a persistent crash on startup.

I'm not sure exactly what borked my game, but big, foundational mod projects like Cyber Engine Tweaks need to be updated with each major patch in turn, and some users in the past have reported similar crash on startup issues to what I experienced. Mod author yamashi has noted on the mod's page that they will be working on a patch 2.0 version of Cyber Engine Tweaks in the coming days.

In the meantime, if you're a returning player, you may want to preemptively pull the nuclear option and do a clean install of Cyberpunk 2077 following CD Projekt's own instructions. The developer recommends:

On the more qualitative side of things, the 2.0 update may change what kinds of mods you even want to have installed. The loot auto-leveling mod I was using has been outmoded by 2.0's new streamlined tier system for gear, and I've found late game fights to be plenty difficult without the mod I was using that'd set all enemy levels to three above my own. Those were band-aids for Cyberpunk's RPG system woes, while 2.0 is triage.

So give it a few days to a week for mod authors to update your favorite projects and, if you've modded up Cyberpunk, consider a clean install ahead of the curve to save yourself some heartbreak, troubleshooting, and a long download