The next game's protagonist seems like an obvious choice following the success of the Amazon Prime live-action adaptation. The Amazon series followed three main protagonists: Lucy, a naive vault dweller discovering the wasteland for the first time, Maximus, a squire of the Brotherhood of Steel, and Cooper Howard, a former Hollywood actor who mutated into a ghoul after the bombs fell and became a bounty hunter.
[Warning: The following article contains some spoilers for the TV show.]
The latter character has become a fan-favorite, with audiences responding extremely positively to Walton Goggins' performance. The TV show used Cooper Howard as a way to flashback to life before the bombs fell, showing the origins of Vault-Tec's Vault Boy mascot and explaining the meaning behind the iconic thumbs-up imagery. With him being around for hundreds of years, his views of the world were a stark contrast to Lucy's, as he lived through the entire post-apocalypse in the Wasteland.
Each of the numbered, mainline games except for — which followed The Chosen One, who was the grandchild of the first game's protagonist — have followed a vault dweller as they venture out into the wasteland. A new spin-off should let players assume the role of a ghoul, with plenty of story potential. As ghouls have an extended lifespan, the game could span many years or decades instead of days and weeks, showing changes in areas and their populations over time.
Other spin-offs have followed non-Vault dweller protagonists, such as a member of the Brotherhood of Steel in, and a courier in.
There are also several new gameplay elements that could be incorporated by playing as a ghoul. Besides their prolonged lifespans, ghouls are no longer harmed by low-level radiation and even receive physical benefits when exposed to it, but there's also the risk of transforming into a feral ghoul. The TV series — which its creators and Bethesda's Todd Howard have stated is canon to the games — explained that Cooper
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