Resident Evil 4 Remake: How To Earn S+ Rank On Professional Difficulty | Tips & Tricks

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Earning an S+ Rank on Professional Difficulty is the toughest challenge in Resident Evil 4 Remake. If you can finish the story in less than 5 hours and 30 minutes while saving less than 15 times total, you can conquer the highest peak of RE4 and unlock the infinite ammo cat ears accessory. As long as you’re skipping cutscenes and blazing through the story, you can safely complete the game in a little over 4~ hours, and we’ve collected lots of tips to help you crush the Illuminados with time to spare. Here are the simple tricks to get you on track.

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Professional Difficulty is the highest difficulty in RE4. It is unlocked by completing a single run of the story. On Professional Difficulty all knife parries must be perfect — the timing is much tighter. Autosaves are also disabled.

To overcome the challenge, I highly recommend completing Hardcore and a normal Professional run as practice. It isn’t required — you can brute force through long sections between saves — but the extra bonuses will help. Here’s what you need to know before attempting your S+ Run.

You’re limited to 15 saves total. Here are my recommendations for best places to save. You can change your plans, but I also recommend saving less often in the early game and saving your saves for later. The early game is the hardest — it becomes slightly easier once you gain access to the Handcannon and can quickly kill most threats you absolutely must deal with to get key items.

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