Mizora is a cambion, which means that if you 'kill' her, she'll just reawaken in Avernus. So, if you want to break Wyll's pact with her in Baldur's Gate 3, lopping off her head isn't an option.
However, one fan has found an exploit that lets you murder Mizora in cold blood without damning Wyll. It bugs his quest out and doesn't reward you with much, but if you've been desperate to clip her wings, it's a viable enough strategy.
There are only three steps you have to follow to pull this off, and they're pretty simple:
Following this strategy, Mizora will teleport away, ending the combat, and then return moments later as a disintegrating corpse. Voila, you killed her and saved Wyll.
Other players recommend infecting her with contagious diseases, turning her to stone, or turning her into gold.
"Congratulations, this annoying devil can no longer bother you or Wyll!" Finnick00 wrote. "Wyll seems to have absolutely no clue what has just happened [though]. PS: don't do this if you haven't finished Wyll's quest. My poor boy's buggy questline might be even more broken."
Killing Mizora this way will net you one singular point of XP. To make matters worse, she has no loot. It's probably not worth the hassle unless you want the bragging rights or are planning to go on a killing spree across the Sword Coast, cutting down absolutely everyone in your path. Devils included.
Baldur's Gate 3 is the long-awaited next chapter in the Dungeons & Dragons-based series of RPGs. Developed by Divinity creator Larian Studios, it puts you in the middle of a mind flayer invasion of Faerûn, over a century after the events of its predecessor.
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