This might actually beat the Owlbear elbow-drop as Baldur's Gate 3's most creative kill, utilising a decidedly mid magic item to deal hundreds of damage, taxing a central villain so hard they just die.
This hairbrained strat comes from GoldenThane, who posted their kill to the Baldur's Gate 3 subreddit yesterday. The Twist of Fortune mace—which you pick up from the Tolltaker boss in the same Act—is an economic equaliser with a special action called «Blood Money», which deals an extra 3 piercing damage per 300 gold your victim is holding.
Usually, this doesn't do much. Some targets might have a few grand kicking around for a nice damage bonus, but it's hard to glean someone's wealth when you're already in a brawl with them. It's also a once per short rest ability, so it's not like you can keep fishing for gold.
If you have a lot of disposable income kicking around, however, you can launder your wealth into the pocket of most characters by reverse-pickpocketing them. This is especially funny when you consider that 15,000 gold weighs 15kg in game, which is a lot of weight to subtly add to someone's bags—the best part is that it doesn't even require a skill check like taking something out of their pockets does. Maybe Thorm just really needed the money for Isobel's college fund.
While the damage numbers aren't that impressive on screen, that's 50 instances of three damage for a meaty 150 smack. Hilariously enough, the Illithid passive «Cull the Weak» triggers for each separate application from the toll taker, adding a whopping 50d4 (50-200) psychic damage on top.
As user Spedwards points out, the implications of this are dangerous. You could hypothetically equip other items that apply damage like Cull the Weak to nuke
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