Young Sheldon reveals what happened to Missy after The Big Bang Theory. Sheldon's sister was the first member of his family to appear in the original sitcom, coming to the show as early as season 1, episode 15, «The Porkchop Indertiminacy.» Since then, she appeared sporadically throughout The Big Bang Theory's 12 seasons on the air, and her story continues through the spin-off prequel, Young Sheldon.
Young Sheldon covers Sheldon's first year of college in season 4, which means that he spends much of his days away from his family, particularly his siblings. That being said, the show still finds ways to have the characters interact, since their family dynamic is a core part of the spin-off series and is important to truly understand Sheldon's quirks and oddities. The Cooper twins spent a considerable amount of time together during summer, but now that they're going to different schools, Young Sheldon relies on their shared time at home for interactions.
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In the Young Sheldon episode, «A Pager, A Club, And A Cranky Bag Of Crinkles,» Sheldon and Missy shared a couple of scenes together since they sleep in the same bedroom. As Sheldon pondered about his dilemma of having to find and join a new school club as a way to stop hanging out too much with Dr. Linkletter, he asked his sister how her social life was going at school. Unlike him, Sheldon's sister is naturally sociable. While she's not book smart, she's empathic and agreeable, which makes it easy for her to find friends. This is why she didn't have the same issues that her brother was having — something that irked Sheldon. In the narration, adult Sheldon inadvertently revealed that Missy
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