Late last year Twitch began to take the issue of gambling streams on its platform seriously, issuing new guidelines that prohibited such content and triggering an exodus of content creators that gambled on-stream. This saw major figures such as xQc, a hugely popular Canadian streamer who often gambles big money and admits he has a problem, move over to Twitch rival Kick, which allows gambling (though the $100 million definitely helped).
Twitch has now begun to get more laser-focused on these guidelines, and has issued a new edict that prohibits streamers from either promoting or being sponsored by Counter-Strike: Global Offensive (CS:GO) skin gambling sites. Estimating the size of this grey industry is a near-impossible task, but it's fair to say it is enormous, enormously popular, and has been a part of the CS:GO scene pretty much since Valve added skins (heck, I've gambled CS:GO skins in the past via sites that let you bet on tournament results). There are professional CS:GO players and teams sponsored by these outfits (such as G2 esports).
Even if no-one knows exactly how big it is, the size of CS:GO skin gambling has made it an especial focus for those who believe gambling should have no place on Twitch. There is also the age factor: Because Twitch audiences skew young there is an argument that skin gambling content is effectively being advertised to minors.
There are many types of skin-related streams, because CS:GO players are just very interested in skins generally. These rules will apparently not affect the standard format whereby streamers buy a whole bunch of keys and stream themselves opening crates: some draw an equivalence between CS:GO crates and gambling, due to the roulette-like spinner that reveals what
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