A seemingly innocuous detail that Doctor Strange notices about Gwenpool implies there is more to Deadpool's origin than previously suspected. The visual cues from one issue hint that Wade Wilson may not originally be from Earth-616, especially when considering that his past is riddled with contradictory details and falsities.
Gwenpool, also known as Gwendolyn Poole, is a Marvel fan from «the real world» who was mysteriously transported into Earth-616. Much like Deadpool, Gwen is known for her fourth-wall-breaking antics and meta humor. Gwenpool and Doctor Strange's paths first cross in The Unbelievable Gwenpool #3 by Christopher Hastings and Gurihiru. In this issue, Gwen is unable to get her mercenary paycheck by M.O.D.O.K. and she needs her comic book citizenship from her old reality. Strange immediately realizes Gwen is from a different reality and he uses his powers to transfer every trace of Gwenpool's existence to her new reality. It's completely in the realm of possibility that Doctor Strange would recognize a dimension-hopping character. However, the way that he recognizes that Gwen isn't from Marvel's Earth-616 completely calls Deadpool's backstory into question.
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Gwenpool's tell that alerts Doctor Strange to her other-worldliness is her speech balloons. He can see her speech balloons and notices that they're pink, which is in sharp contrast to the white bubbles of everyone around her. In fact, Gwen even sees her speech balloons briefly when Doctor Strange takes one for a spell casting. He describes her visual speech as a "cosmic accent" that solidifies she's from another world. Both she and Deadpool share uniquely colored speech balloons, with
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