Although has a wide variety of items, not all of them will be vital parts of a playthrough, but it can often be hard to know what to hold onto. Ingots and gems are common finds in, which may set up the expectation that they'll be used in some kind of crafting system, either through the game's own Combine function or through one of the many blacksmith NPCs such as Dammon. Players who do hold onto these items, however, will inevitably end up having to contend with a cluttered inventory and carry weight restrictions.
Outside of items with clear use cases, such as weapons, accessories, and armor, also has a number of seemingly useless items for players to pick up. In some cases, like with using the Adamantine Forge, items that don't have a clear use at first can be vital for certain quests later on. However, holding onto too many items can leave players encumbered and lead to unwanted inventory management. For items that have no real use, players will likely be better off simply selling them to vendors — or just not picking them up in the first place.
Ingots and gems will be a common find for any player diligent about gathering loot in, which may lead to the belief that they have extra uses. Unfortunately, outside a few very specific exceptions, ingots and gems are only useful for their gold value. Any scenario where there's actual utility to be found is typically very clear, like the Infernal Iron, which can be used for Karlach's personal quest as well as to gain some rare loot from Dammon. Otherwise, it's safe to sell these items whenever they're picked up.
It can still be a lot to wrangle, as ingots and gems become a very common reward as progress is made through the game. They can be found semi-randomly in many of the game's minor chests, on the bodies of slain foes, or even just lying out in the open. It can still be worth picking them up just to sell them to vendors when the opportunity arises, but there's no reason not to immediately mark the vast majority as
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