The first act in the Diablo 4 campaign takes place in the Fractured Peaks. Early on, you'll be able to visit the region's capital, Kyovashad, which has numerous mechanics for you to try out.
Here's our Diablo 4 Kyovashad hub guide to help you with the many features in this city. The Diablo 4 Kyovashad hub is unlocked early in the campaign.
Basically, you'll meet a priest named Lorath Nair while you're in the hamlet of Nevesk. After Lilith's involvement is revealed, you'll travel northeast, eventually reaching the city of Kyovashad.
There, you're told to inscribe your greatest sin on a tablet (i.e., fear, anger, pride, greed, or nothing but scribbles). Only then will the gates be opened, and you can continue onward with the main quest.
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