Should Harry Osborn make his MCU debut at some point in the next trilogy, the dynamic between him and Peter will be very different from both the movies and the comics as Spider-Man: No Way Home has made Spider-Man aware of the Osborns’ Green Goblin history. By bringing in five multiversal villains and the other two live-action versions of Spider-Man, No Way Home has taken Tom Holland's series of films to the next level and left audiences eager for where the franchise goes next. While details about the next Spider-Man movie are still a mystery, Sony and Marvel have already announced that they are continuing their successful partnership.
The friendship between Peter Parker and Harry Osborn is one of the most important pillars in the Spider-Man lore. Focusing on Peter's high school life, the first Spider-Man trilogy in the MCU chose not to introduce Harry, who in the comics only gets to meet Peter in college. Another obvious reason for not utilizing Harry or an MCU-Norman was to avoid reusing already worn-out villains from the Spider-Man franchise. Although a key player in several Spider-Man stories, Harry had already appeared in four of the other five films leading up to Spider-Man: Homecoming. Now heading into a second trilogy, it might be the time for Peter to finally meet Harry in the MCU.
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Whenever that encounter happens, it will already be different from all the previous iterations— including in the comics. The events of No Way Home have shown Peter Parker that, at least somewhere in the multiverse, the name Osborn is tied to the Green Goblin. That can cause Peter to meet Osborns already anticipating how dangerous that family could be.
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