Doctor Strange's memory-wiping spell at the end of Spider-Man: No Way Home protected Peter Parker's loved ones by giving him his secret identity back, but how will this affect Spidey's past MCU villains? Spider-Man has one of the most extensive galleries of famous villains, and the MCU has already introduced a large portion of it to live-action. However, at least six of Spider-Man's greatest foes come from alternate realities in the multiverse, while the rest inhabit the home universe of Tom Holland's Peter Parker.
What exactly happens to the villains of Spider-Man: No Way Home after being sent back to their original universes isn't explained by the movie, but what's for certain is that Green Goblin, Doctor Octopus, Sandman, the Lizard, and Electro redeemed themselves before parting ways with the three Spider-Men. On the other hand, Eddie Brock left a piece of symbiote before returning with Venom to Sony's Spider-Man Universe, while villains like Vulture, Scorpion, Shocker, and possibly, Mysterio, have probably been affected by Doctor Strange's memory spell without having interacted with Spider-Man.
Related: No Way Home: Why Doctor Strange's Astral Spell Is So Weak Against Spider-Man
None of Spider-Man's MCU villains may know who Peter Parker is anymore, and they won't be able to take advantage of his personal life, but their hatred for Spider-Man will remain the same — or maybe increase even more. For instance, Adrian Toomes, a.k.a. the Vulture, refused to reveal Peter Parker's identity to Scorpion out of respect for saving his life at the end of Spider-Man: Homecoming, but now that the personal connection between Peter and his ex's father is gone, Vulture and Scorpion could become a bigger threat if they get out of
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