While the Resident Evil series is full of bizarre, terrifying creatures, it's important to remember that those creatures all originated from real-life concepts. The t-Virus was born of retrovirus research, Las Plagas was a revived species of parasitic arthropod, and the Mold is, well, mold. Keeping this in mind gives us an idea of how these malignant agents create the monsters that they do, as well as how they function beyond that.
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In the case of the Mold, while some of its functions and abilities can seem overtly supernatural, they do have a basis in at least some degree of real science. Understanding the process behind those functions can help make the unusual monsters that originated from it seem at least a little more sensible, at least within the bounds of the Resident Evil universe.
The origin of the capital-M Mold we know in the Resident Evil series can be traced back to a single supercolony located in a cavern system beneath a village in Eastern Europe. Anyone who's ever had water damage in their home knows that mold can spread quickly in the right conditions, but based on the sheer volume of mold that dwells within these caves, it's possible that it had been growing down there for at least a millennium. Around the 15th century, an ancient society took up residence in these caves, though after a period, they all disappeared, more than likely having been absorbed into the Mold's biomass.
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On its own, the Mold isn't an outright malevolent force. It's just a fungus, doing what fungi do; finding a comfortable spot and spreading itself out to feed. Of course, the same could be said for the original
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