While Son Goku of Dragon Ball is generally regarded as the strongest character in all of manga and anime, there is one Naruto villain who'd be able to take him down. When manga fans compare the power levels of manga characters, a theoretical battle between any high-level character and Goku is inevitable, and usually the debate ends with Goku coming out victorious. Saitama of One Punch Man is perhaps the only character that fans agree could beat the Saiyan. However, strength isn't the only factor that matters, as one Naruto villain proves.
Goku is the protagonist of Akira Toriyama's critically acclaimed Dragon Ball series. He is a martial artist who has the power to destroy entire planets. Each arc of Dragon Ball usually concludes with Goku or another character powering-up and gaining a new form or ability. Goku's most recent and most powerful upgrade is called Ultra Instinct and allows him to fight without having to process his actions, adding incalculable speed to his already god-tier power.
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As for the Naruto villain that could defeat him, it is none other than Itachi Uchiha. Itachi's full power potential is unknown due to the fact that he died at a young age, and that he was infected with an unknown sickness. Despite this, he was still one of the series' most powerful and proficient ninja, and is a master of more than a few techniques. Itachi would probably lose to Goku in strict hand-to-hand combat, although he could hold his own for a while, but Itachi's true strength lies in his non-physical capabilities. His Sharingan grants him a number of powerful jutsu and illusory tactics that Goku would succumb to, as the Saiyan's power mostly lies in his
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