The side quest «Scientific Methods» is the earliest side quest that Isaac can take on in . However, it will not be the first one he is able to complete. That said, this side quest will allow Isaac to learn more about Nicole and her own investigation into what has been going on aboard the Ishimura.
The side quests are one of many new additions to the . They all give Isaac an extra leg up for finishing the game, but they also flesh out the lore of the original. The extra items and upgrades Isaac can earn through these quests make them worth it, as they will allow Isaac to survive his horrifying journey longer than he would without them.
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The Scientific Methods side quest can be activated in Chapter 2 — Intensive Care. While Isaac is on the Medical Deck, he can find Nicole’s Office after clearing out the Main Laboratory. Nicole’s Office is near the stasis refill chamber. Once inside, pick up the audio log, and it will begin the side quest in .
After that, Isaac will have to find Nicole’s Secret Office, which is within the Diagnostics Room of the ER. Getting to the ER is part of the main objective, and Isaac will have upgraded his gear in to unlock Kinesis by now. Once in Diagnostics, there will be operating tables scattered around, one of which has a stuttering hologram of Nicole. The objective will update to following the hologram. YouTuber Gamestra shows players how to follow Nicole through the wall by using the circuit breaker and Kinesis to get through it. A scene will play out once inside the Deprogramming Suite.
Once on the Engineering Deck in Chapter 3 — Course Correction of activate the side quest to reveal the objective to help lead Isaac to the
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