While the Guardians of the Multiverse were assembled in What If...?to protect the MCU's countless realities, the fact the team doesn't seem to appear in Doctor Strange in the Multiverse of Madness suggests to some that they were maybe defeated after they stopped Ultron and Killmonger from destroying every universe. It's not a secret that the concept of the multiverse has been put front and center in Phase 4 of the MCU. It allows new and familiar iterations of characters to share the screen and it paves the way for mind-blowing stories that wouldn't be possible without the use of reality-bending shenanigans.
After Avengers: Endgame introduced alternate timelines to the MCU, WandaVision teased the role sorcerers and witches had over the multiverse, and Loki explored how crazy the variants of one single character could be, What If...? fully focused on some of the endless realities that neighbor the MCU's main universe. While What If...? functioned as an anthology series, it also assembled the Guardians of the Multiverse — an Avengers-like team of multiversal variants who vowed to protect the multiverse from threats like Ultron.
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However, Doctor Strange in the Multiverse of Madness shows no signs of including the Guardians of the Multiverse. Only Captain Carter and Supreme Strange seem to have a minor role in the Doctor Strange sequel, and they don't seem to be working together. Further, the Illuminati appear to be the ones overseeing every reality. Here's why this is a bad omen for the Guardians.
The Guardians of the Multiverse succeeded in neutralizing the Arnim Zola-infected Ultron, but not before being betrayed by Killmonger. Supreme Strange kept
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