Challenging PVE content in Destiny 2 comes in a few different flavors, from raids to solo lost sectors to Grandmaster Nightfalls. The latter is actually fantastic for farming powerful Adept weapons that are on rotation, such as the Palindrome, PLUG.ONE 1 and the Uzume R44 and more.
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However, Grandmaster Nightfalls currently represent the most challenging form of PVE in Destiny 2, and going in blind will usually yield zero results.
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