offers players numerous dialogue choices that can influence their journey in the Night City, but there are some secret decisions that can badly impact Panam's questline. V first meets Panam after Rogue suggests that the nomad can help the mercenary captures Anders Hellman. Despite the rough start, the two people quickly get close, and Panam starts to ask for V's assistance on several occasions.
provides several romantic interests depending on the protagonist's gender, with Panam being an option for male V. Players can flirt with Panam, suggesting the share a room in Sunset Motel bar at the end of the Ghost Town mission. If the right dialogue choices and relationship options are picked, V and Panam can eventually enter a relationship. The player can even receive NSFW texts from Panam in , which is one of many features added in the 1.5 patch. If the player doesn't want to help Panam, however, they can prematurely end her questline by making some hidden decisions.
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In the "" quest, Panam contacts V about needing their help to save Saul, who the Wraiths have kidnaped. V needs to infiltrate the Wraith camp while Panam remains at a distance to provide sniper cover fire if things go wrong. If players perform the mission properly, they can rescue Saul and return him to the Aldecados, but there is a hidden option where players can ditch Panam outside the Wraith camp. After a few in-game days pass, Panam eventually sends a message cursing V for betraying her and says that Saul is dead. This action will cause the quest to fail and prevent players from romancing Panam in .
Another secret option is also available in 's "" mission, where Panam asks V to help her and Mitch
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