It’s possible (though incredibly difficult) to complete Baldur’s Gate 3 with a single character. Some classes for a Solo Challenge run though, are much better than others at getting the job done.
Baldur’s Gate 3 gives you many options for a Solo Challenge run, as there are tons of items and environmental effects that can be used to give you an advantage over groups of enemies. Just remember that Baldur’s Gate 3 uses the Dungeons & Dragons 5E action economy, so being outnumbered is a massive disadvantage for a player character.
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There are a few variants of this concept, but a Rogue + Warrior-type is the overall gist of the idea. Rogues have access to lots of Skills, which you’ll need with only a single character, and their Cunning Action is incredibly useful for evading Attacks of Opportunity, crossing a lot of distance quickly, and hiding in the middle of combat. They can also deal extra damage each turn via Sneak Attack, which is great when combined with Cunning Action: Hide to gain Advantage.
The addition of a warrior class brings much-needed bulk to the character in the form of more hit points and better armor/weapon options. The Fighter will give free healing via Second Wind, access to spells if Eldritch Knight is chosen, access to more combat abilities if Battle Master is chosen, and, more importantly, Action Surge, giving the character some much-needed extra Actions in combat.
The Barbarian is another great option, as they can make
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