Despite vampirism initially believed to be permanent, The Vampire Diaries saw four different vampires using the Cure through the show, each with various outcomes. Over the years and through its end with season 8, The Vampire Diaries expanded its characters to include various supernatural creatures, and the series developed a complex (albeit sometimes convoluted) canon. One integral component of the show's mythology was the Cure for vampirism, which was used on several occasions and became a significant plot driver more than once.
The Cure, long thought to be a myth, was revealed to be very much real in The Vampire Diaries season 4. A significant portion of that season involved various characters trying to find it to use for their own ends. Even beyond the fourth season, however, the Cure continued to pop up and impact the plot throughout the following seasons.
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Understandably, giving up one's vampirism and thus one's immortality and supernatural powers is a big deal. That didn't stop a number of characters in The Vampire Diaries from wanting to take it, however, yearning for a human life. Other vampires saw it as a weapon, a means to get rid of a powerful threat or to be used as a bargaining chip. Whatever the intent of using the Cure, those who did use it were profoundly changed. Here's every character in the Vampire Diaries who used the Cure and what happened to them.
Far from being discovered thanks to new science, the vampire cure was very old. It was created by the powerful witch Qetsiyah, Bonnie Bennett's ancestor, thousands of years ago in order to punish her immortal lover, Silas, for betraying her with another woman. The Cure
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