Sheldon had a very close relationship with his Meemaw, but she didn't attend his and Amy's wedding in The Big Bang Theory. Years of dating that even included a brief separation ultimately led to the couple tying the knot at the end of The Big Bang Theory season 11. Aside from their closest friends, the celebration was attended by the pair's respective families, but there's one particularly notable absence from Sheldon's side of things — his grandmother, Meemaw.
Long before she made her physical debut on The Big Bang Theory, Meemaw was already an established character on The Big Bang Theory, thanks to Sheldon's stories about her. While the socially-inept genius isn't known for being affectionate, he's very open about his love for Meemaw — even dubbing her as his favorite out of all his living family members. It was only in The Big Bang Theory season 9, episode 14 titled «The Meemaw Materialization» when she officially appeared after learning about Sheldon's heartbreak from Amy splitting up with him.
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Given how important Meemaw is to Sheldon, it's odd that she didn't attend her grandson's life milestone when Sheldon married Amy in The Big Bang Theory season 11 finale titled «The Bow Tie Asymmetry.» In the episode, all of Sheldon's remaining family members traveled to Pasadena, including Georgie, with whom he hadn't been on speaking terms for a long time. Given the significance of the event and the clear effort that the show's writers put into gathering nearly all of Sheldon's family into The Big Bang Theory's Sheldon and Amy wedding episode, it's especially surprising that Meemaw is missing. As it turns out, there are specific reasons
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