In Season 5 of Diablo 4, not only are we getting tons of new Uniques, we're getting a new endgame mode — and that means new target-farming strategies! Through rigorous testing on multiple classes, we've uncovered where all of the new Uniques can be target-farmed, and while this information may change once Season 5 goes live, for now, we've got our answer.
Diablo 4 Patch 1.5.0 Datamined Changes Patch 1.5.0 PTR Hotfix — Additional Infernal Compass Sources
As stated by Blizzard, all of the new Uniques «can be earned by slaying enemies across Sanctuary», but certain sources (like Infernal Hordes and the Boss Ladder) have increased drop rates which allow for target-farming any of these new Uniques. Patch 1.5.0 also added the ability to obtain all Uniques and Mythic Uniques from gambling, Whisper Caches, and Helltide Chests.
Here are the target-farming sources for all new Uniques introduced with Patch 1.5.0 in Season 5. Remember that these sources are subject to change before the launch of Season 5 on August 6!
Grigoire, The Galvanic Saint can be found in the Hall of the Penitent, located in Dry Steppes, just south of its capital, Ked Bardu. Collect 2 Living Steel (World Tier 3) or 5 Living Steel (World Tier 4) from Helltide Chests to fight against Grigoire.
Grigoire, The Galvanic Saint Boss Guide
After finishing the Infernal Hordes quest line, which starts with The Eyes of the Enemy quest in Zarbinzet (Hawezar), players can use an Infernal Compass to face the Infernal Hordes in the new endgame