Doctor Strange and America Chavez's trip through the multiverse in Doctor Strange in the Multiverse of Madness may have included a hint at two famous Spider-Man variants. From Stephen's powerful counterpart, Sinister Strange, to the show-stealing Alligator Loki, Phase 4 of the MCU has made it clear that the multiverse allows for the existence of countless different versions of each Marvel character. Although Loki, Scarlet Witch, Doctor Strange, and Spider-Man have already met some of their infinite variants, there are many others that could still show up.
Spider-Man: No Way Home only introduced two new universes to the MCU: Andrew Garfield's and Tobey Maguire's. Had Doctor Strange not contained his spells, however, many other variants from unknown universes could have arrived. After all, Spider-Man is more closely connected to his multiversal variants than other Marvel characters. This is why spider-related characters such as Miles Morales and Spider-Gwen have made a name for themselves in Marvel comics after arriving from a different universe.
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While Doctor Strange in the Multiverse of Madness didn't feature any Spider-Man variant per se, it may have shown at least two of the universes they inhabit. When Doctor Strange and America Chavez fall through different universes during their escape from Scarlet Witch, one of the realities they crash through before landing in the MCU's 838 universe looks like a black-and-white film, and another looks like a futuristic, moonlit metropolis. These could be the Noir universe, home of Spider-Man Noir, and the 2099 universe, home of Miguel O'Hara.
Spider-Man Noir is an investigative reporter with roughly the same origin story
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