Don't expect anything like the Mass Effect trilogy ever again - BioWare doesn't have any plans for it. Or at least, a BioWare veteran who has since left the company doesn't believe that it's likely we'll get one again, saying that it was never discussed while he was there.
Mac Walters, who worked on Mass Effect from the first game all the way to the Legendary Edition trilogy, discussed this in an interview with Eurogamer. Despite the initial Mass Effect trilogy being such a huge success, Walters says that while he was there, BioWare wasn't planning anything similar, saying, "We've done that."
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"I don't think we've ever talked about that again," says Walters, asked if BioWare would ever release another game as part of a planned trilogy "We've done that - what else can we do?"
This came after he explained how the first Mass Effect was always intended to be the first part of a three-game story, with the next two mapped out alongside the first. While some specifics wouldn't be ironed out until Mass Effect 3's development - such as the controversial ending, which was redrafted multiple times - it was always envisioned that Shepard's story would take three games to complete. The first game's ending was just the beginning.
However, judging by Walters' comments here, this is a development method that BioWare has abandoned.
That being said, even Dragon Age: Origins worked nicely as a standalone game, and that was released before Mass Effect 2. In fact, to make Dragon Age 2 possible, several story elements from the first game had to be retconned, such as the Warden possibly staying in Ferelden to serve the monarch, and Anders remaining with
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