Witcher 3: Every Mutation, Ranked By Their Usefulness

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The Blood and Wine expansion added a lot to The Witcher 3, including new characters, the Skellige Gwent deck, and one of the most beautiful locations in the game, Toussaint. Another excellent addition, though, was the mutations. These powerful new abilities became the focal point of every The Witcher 3 character build going forward.

The Witcher 3: Things Most People Miss During Blood & Wine

There are 12 mutations in total, which all have their own distinct ways of improving the player. But they are not created equal. Some of them are far more useful than others. And as players can only equip one at a time, it's important to know which are the best mutations in The Witcher 3.

Updated February 1, 2022 by Mark Sammut: Despite debuting more than half a decade ago, The Witcher 3 still averages above 15,000 simultaneous players on Steam, and that's not counting periods during or after sales that give the game a substantial boost. CD Projekt Red is reportedly working on a standalone Gwent game, so Witcher fans have a lot to look forward to in 2022. Whether someone is playing through the RPG and its expansions for the first or tenth time, they will come across mutations when they get to the Blood and Wine DLC. This article has been expanded to provide more information about each mutation.

Strengthened Synapses is a mutation that improves as Geralt researches the active mutations. As such, it is not really comparable to the other ones, even though it is arguably the most important in the grand scheme of things.

Strengthened Synapses allows Geralt to equip more abilities, although they would need to be of the same type (color) as the equipped active mutation:

Some mutations have a mix of colors, allowing a wider range of abilities to be