Cartoons seem to portray themselves as this magical universe where nobody ages, nothing ever changes to a vast degree, and a lot of the time, the show itself never looks to be heading towards the finish line. There are many factors that go into whether a show continues or not. Sometimes it might be out of the studio's hand, as there is a bigger party pulling the strings of their viewing output.
The biggest cartoon in recent memory to receive an ending was Bojack Horseman. The show only had six seasons, and whether or not it should have had more time, it still managed to wrap things up in its classic reality-driven style. Whether it is through ratings, nostalgia, fan demand, or a return from being canceled, some shows just don't seem to know how to end.
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Adult comedies such as The Simpsons, Family Guy, and South Park are still releasing episodes in 2022, and with the first two lacking in a lot of continuity, it's hard to see them coming to a natural end. South Park may look like the only one of these long-running adult comedies to come to an end due to its release schedule over the last couple of years. Of course, the pandemic halted their schedule, but South Park creators Matt Stone and Trey Parker reduced the number of episodes per season years ago, giving them a continuous story, and now there are shorter seasons and more specials on the way. There has even been a look into the futures of the South Park characters and for a show that's always trying to get itself canceled, it looks like if Stone and Parker really wanted to end their creation they could do at any moment.South Park is a show that could confidently end.
Looking at The Simpsons universe
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