Warning: The following contains SPOILERS for Superman and Lois season 2, episode 11.
A major DC Comics rule regarding how Kryptonite affects Superman was broken in Superman and Lois, suggesting a different set of physical laws for the Arrowverse. Traditionally Green Kryptonite has been said to render Superman completely powerless, in addition to causing him great pain. However, one scene in Superman and Lois bucked this trend with Kryptonite having a notably different effect to the Kryptonian in the Arrowverse series.
While there are several types of Kryptonite with different effects depending on the color, Green Kryptonite is the most famous. The fact that Green Kryptonite takes away Superman's powers is well-known even to people who don't read comics. Indeed, referring to someone's greatest weakness as their "personal Kryptonite" is arguable just as popular of an idiom in the modern age as the phrase "Achilles' heel."
Related: Superman & Lois Season 2, Episode 11 Ending Completely Changes The Show
Despite this, one scene in the Superman and Lois season 2 episode «Truth and Consequences» confirmed that the Arrowverse Superman was far from powerless when exposed to Green Kryptonite. The Jonathan Kent of Bizarro World, Jon-El, launched a sneak attack on Superman which left his chest embedded with Green Kryptonite shrapnel. He also stabbed the Man of Steel with a Green Kryptonite crystal. Superman was incapacitated until Lana Lang was able to pull the shards out of his wounds, but he was still able to hear the often imperiled Lois Lane, as she shouted his name while Jon-El attacked her and their sons, demonstrating that in the Arrowverse, Kryptonite hurts Superman, but does not strip him of his powers as is normally
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