Warning! Spoilers ahead for Captain America: Symbol of Truth #2
In the Marvel Universe, Deadpool is known as someone who can take a lot of punishment. So out of everyone, he would know the worst place to be stabbed.
Despite the numerous copycats spawning in his wake, Deadpool is fairly unique in the Marvel Universe. He fits in a lot with the X-Men line of books, but he's not technically a mutant. He was a foul mouth special forces soldier that underwent a brutal procedure in order to activate a latent mutant ability to have incredible regenerative properties that rival even that of Wolverine's. According to Wade's creator, Deadpool and Wolverine are almost twins in this regard. Given that many think Deadpool is insane, for him to have an enhanced healing factor results in him being fairly careless when it comes to taking damage. This also means that it's very difficult to torture and interrogate Wade as he is both psychologically crazy and can take a ridiculous amount of punishment.
Related: Deadpool's Assassin Daughter Returns to Marvel in X-Men 2099
In Captain America: Symbol of Truth #2 by Tochi Onyebuchi and RB Silva, Captain America Sam Wilson, rescues Deadpool from a facility. Upon seeing Cap, Deadpool reveals that he's glad Captain America arrived when he did because Deadpool was stabbed in the colon, which is leaking fecal matter and causing the whole room to smell.
This is so ridiculously absurd that only Deadpool would make a comment like this. First off, if a normal person were ever stabbed in that area they would die either from blood loss or infection relatively quickly. Also, if anybody else with a healing factor were stabbed there the same thing would have happened. Except, since Deadpool has no social
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