Captain America's Super Soldier Serum Weakness Makes No Sense

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While a scientific marvel imbued the weakling Steve Rogers with the strength he needed to become Captain America, it seems a key part of the process is still a mystery. On several occasions, Rogers has found his Super Soldier serum negated, only to be met with drastically different results.

The origin of Captain America is one of the most well-known comic book stories of all time. The scrappy young patriot Steve Rogers wanted nothing more than to serve his country and enlist in the army. As a 4F reject, he was turned away until he got the chance to take part in an experiment that would turn him into the most powerful soldier the United States military had ever seen. The mysterious process that turned Steve into a superhuman was largely lost after its creator, Dr. Erskine, was shot and killed, leaving Steve the sole product of his work. Though there have been several super-soldiers after Captain America, many of them ended up corrupt. It appears that even the creatives at Marvel are mystified by how the Super Soldier serum works, particularly in regards to what will happen to Steve if he suddenly finds himself without it.

Related: New Captain America Recreates Iconic Meme with Steve Rogers

Captain America #21 by Rick Remender and Nic Klein sees a climactic battle between Captain America and a villain called the Iron Nail. The Iron Nail uses a tendril to physically remove the serum from Steve's body, aging Captain America until he reached the age he would chronologically be if he had not been frozen. However, it wasn't the first time Steve suddenly found his body altered due to a lack of serum. In Steve Rogers: Super Soldier #2 by Ed Brubaker, and Dale Eaglesham, a villain known as Machinesmith captured Rogers and used