From an LGBTQ+ perspective, Fallout 4 was a bit of a mixed bag. While it brought romances to the series, not gating any of them behind gender, it isn't actually possible to play as a character who is gay or asexual. If you're a woman, you have a husband, and vice versa.
But thanks to this mod from Nexus user LeahTheUnknown, you can finally add some diversity to the Commonwealth. Most gendered pronouns in Fallout 4 can now be changed to they/them, making it possible to play as a Sole Survivor
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