Throughout his history in the Marvel universe, Deadpool hasn't been the easiest character for audiences (or even characters in the universe) to understand. With a personality that borders on psychotic, Deadpool suffers a psychosis brought on by the nature of his healing factor. His accelerated cell regeneration affects the neurons in his brain, damaging them. As a result, his mental capacity decreases every time that his body heals from a grueling battle.
The more often Deadpool heals, the further detached from reality he becomes. It can be considered a large reason as to why he's able to break the fourth wall so often (canonically speaking, at least, otherwise writers just like having fun being meta with Deadpool's thoughts), hallucinate, and fantasize in the middle of a monologue while struggling to distinguish what's real.
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For fans of Scrubs, that may sound a lot like the sitcom's main character, J.D. played by Zach Braff. Writer Fabian Nicieza and artist Patrick Zircher themselves noticed the parallels between Deadpool and J.D. as they were crafting Cable and Deadpool #4. In it, Deadpool reveals that Scrubs is actually his favorite sitcom. What on the surface reads as a simple nod to an Emmy-winning comedy manages to help readers get a better understanding of what's actually going on inside of Deadpool's head for once, as Scrubs is told through the guise of someone who's equally detached from reality, but at the very least, (unlike Deadpool) sane.
The parallels between Deadpool and the sitcom's lead character are easy to spot, most especially concerning the use of their inner monologues. Much like Deadpool, J.D. gets deep enough into the
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