Warning: The following contains SPOILERS for Superman and Lois season 2, episode 7, «Anti-Hero.»
The source of the X-Kryptonite super drugs is a mystery that Superman and Lois has ignored to the point of it being a major problem for the season 2 storyline. Also known as Yellow Mist, the performance enhancer has come to be a major concern in several of the series' subplots. This makes it all the stranger that nobody seems to have been investigating how a seemingly rare space rock is being refined and distributed with apparent ease by some unknown criminal mastermind.
Originally introduced in Superman and Lois season 1, X-Kryptonite is an extremely rare version of Kryptonite most commonly found in the Shuster Mines of Smallville, Kansas. While most forms of Kryptonite in the Arrowverse only effect Kryptonians, X-Kryptonite has the ability to give ordinary humans the same powers that Kryptonians acquire under a yellow sun. Originally, this was presented as a lethal transformation, as only the citizens of Smallville (who had been exposed to X-Kryptonite radiation for decades) were capable of being altered into suitable host bodies for Kryptonian personalities via the Eradicator protocol. However, at some point between the first two seasons of Superman and Lois, someone discovered a way to process X-Kryptonite into the designer drug Yellow Mist, and began selling it as a performance enhancer and party drug to the teenagers of Smallville. The drug also came into the hands of Phillip Karnowsky, a dealer in illegal arms and narcotics, who used the drug to briefly become a match for Superman in the season 2 episode «The Ties That Bind.»
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