The developers of say most of the game can be completed with just one of its dual protagonists, but players are better off experimenting anyway.
Although it's not the first time an game has had multiple playable characters, it is the first time the two of them have had such radically different playstyles.
Naoe, the shinobi, embodies the classic style, specializing in stealth and secrecy. Yasuke, meanwhile, is a heavily-armored samurai who walks right into the heart of battle, fending off enemies with deft skill, but far less subtlety.
And according to an interview with producer Tu Yang and assistant director Zhu Bijia in , players can complete 90% of the game using just Naoe (or, presumably, just Yasuke), but are much better off experimenting with both protagonists.
There's quite a bit of exclusive content to each storyline, and, although it's technically possible to complete most of the game with just one of them, players will get a more complete picture of the story by dabbling with both.