To remove runes in Diablo 2: Resurrected you need to use a special Horadric Cube recipe. Place the socketed item into the Horadric Cube, along with a Hel rune and a Scroll of Town Portal, then select Transmute. Be warned, this will destroy all of the gems, jewels, or runes in the sockets, but the socketed item will remain intact, and will now have empty sockets. There is no way to remove runes, gems, or jewels from an item without destroying the runes, gems, or jewels.
The Hel rune won’t drop at
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